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Phase

Pre-clinical
Phase One
Phase Two
Phase Three
Available to Patients

Therapeutic Approach

Binding gluten so it’s not absorbed
Breaking down gluten using enzymes
Interrupting the immediate or delayed effects of gluten on the cells lining the intestine
Preventing the enzyme tTG from modifying gluten in the cell​, which helps to reduce an abnormal immune response
Inducing immune tolerance to protect against the effects of gluten by preventing an immune reaction
Interrupting the immune reactions that occur

Status

Active
Discontinued

Associated Websites

Drug Development Pipeline

Drug Development Pipeline

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Last updated May 29, 2019

Therapeutic Approach

Binding gluten so it’s not absorbed

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
BL-7010 (BioLineRx)

END PHASE TWO
Therapeutic Approach

Breaking down gluten using enzymes

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
IMGX-003/Latiglutenase (ImmunogenX)

MID PHASE TWO
KumaMax (PvP Biologics & Takeda Pharmaceuticals)

START PHASE ONE
Therapeutic Approach

Interrupting the immediate or delayed effects of gluten on the cells lining the intestine

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
Larazotide Acetate (Innovate)

START PHASE THREE
Therapeutic Approach

Preventing the enzyme tTG from modifying gluten in the cell​, which helps to reduce an abnormal immune response

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
Name TBD (Sitari/GSK)

MID PRE-CLINICAL
ZED 1227 (Zedira and Dr. Falk)

START PHASE TWO
Therapeutic Approach

Inducing immune tolerance to protect against the effects of gluten by preventing an immune reaction

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
TIMP-GLI (Cour Pharmaceuticals & Takeda Pharmaceuticals)

MID PHASE ONE
Nexvax2 (ImmusanT)

START PHASE TWO
Name TBD (Selecta Biosciences)

MID PRE-CLINICAL
Therapeutic Approach

Interrupting the immune reactions that occur

Pre-Clinical
Phase One
Phase Two
Phase Three
Available
AMG 714 Non-responsive celiac disease (Amgen/Provention Bio)

MID PHASE TWO
AMG 714 Refractory celiac disease type 2 (Amgen/Provention Bio)

END PHASE TWO
CALY-002 (Calypso Biotech)

MID PRE-CLINICAL
Hu-Mik-Beta 1 Refractory celiac disease (National Cancer Institute, Mayo Clinic, University of Chicago Medicine Celiac Disease Center)

START PHASE ONE
Vedolizumab (Investigator initiated in collaboration with Takeda Pharmaceuticals)

END PHASE ONE
BNZ-2 (Bioniz Therapeutics)

MID PRE-CLINICAL
No drugs match your filter selections.