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Celiac Disease and IgA Deficiency

What is IgA Deficiency?

IgA deficiency is a condition in which individuals do not make or have very low blood levels of IgA antibodies, which are responsible for fighting infection in the body. It is estimated that 1 in 500 people have selective IgA deficiency. IgA deficiency can be a silent condition, meaning it has no symptoms, however it can also be associated with a risk of infections, allergies, asthma and autoimmune diseases. Common autoimmune conditions found with IgA deficiency include rheumatoid arthritis, lupus and celiac disease.

What is the Connection between Celiac Disease and IgA Deficiency?

  • People with IgA deficiency should be tested for celiac disease because they are 10 to 20 times likely to develop an autoimmune response to gluten than the general population
  • An estimated 2% of people with celiac disease also have IgA deficiency
  • Those with IgA deficiency should be tested for IgG-tTG antibodies instead of IgA-tTG.  This is because the IgA-tTG test will not be accurate in those with IgA deficiency

Where Can I Learn More?

Do you or a family member suffer from IgA deficiency? You may have celiac disease. Find out now. Take our Celiac Disease Symptoms Checklist.


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